ApoE4 – The Ancestral Allele

For ApoE4 carriers interested in primal diets and science


with 7 comments

Is it an ancestral super-allele or a slow-motion Alzheimer’s death sentence?  It depends what you eat and how you play.

This is a blog for carriers of the Apolipoprotein allele ε4, as well as researchers and others interested.  Our perspective is:

  • Practical – interested in taking action to maximize our health.
  • Primal – we believe that selectively emulating aspects of the hunter-gatherer lifestyle, such as diet, is a powerful general strategy for health, and that this is especially true for us ApoE4s, since it’s a pre-agricultural allele.
The blog was started by Patri Friedman, an E4/E4, because there seem to be no good central resources for E4s to share practical information and research.  Guest posts, links, and academic articles are welcome.  We’re especially interested in finding other co-bloggers to help run the site – so if you’re a health-conscious E4 whose going to be researching your condition anyway, consider joining us and writing up your findings to share with others!
Contact patrissimo-at-gmail.com.

Written by patrissimo

July 15, 2011 at 5:40 pm

7 Responses

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  1. Thank you for putting this together (got here from the Animal Pharm link). The last 3 hours of reading have been enlightening. I am Apo E3/4, and was put through the wringer by my doctor who was just following the research 8 years ago about low fat diets and Apo E4. She was trying to help me, but almost ruined my life. I think disseminating research that paints a clearer picture of what Apo E is and does will be very helpful to others who may be facing the same predicament. I don’t have anything to add to the blog at this time other than gratitude, but if I come across anything of use I will post it here.

    Brooke Fotheringham

    September 16, 2011 at 7:44 am

  2. Hello I’ve just recently found out that I’m APO E4/4. I’m grateful as well to find this blog. My new doctor did some testing on me which I didn’t understand would include genetic testing at that time. So this has become a bit of an unexpected journey for me but I believe at the end of the day, I am glad I know now. I will update with any info that I find.

    Kimberly Brown

    February 14, 2012 at 2:50 am

  3. I refer to your website frequently. Berkeley Heart lab does genetic testing including APO E Gene. The argument on LCHF or Primal diet APO E 3/4 4/4 may be a good thing. On standard American diets it may be a bad thing – Jeff Gerber MD – Denver’s Diet Doctor

    Jeffry N. Gerber, M.D.

    August 2, 2012 at 4:21 pm

  4. Hi,

    It looks like this blog is no longer particularly active (unless there just has not been any relevant recent study involving APO E4).

    I just got my 23andme report and learned that I am APO E4/4. This has thrown my entire lifestlye upside down, as I have been eating Primally for the last 8 months. I have always been lean and healthy (I am 23 years old), and switched to Primal to hopefully increase my energy. I am now fretting over my APO E4/4 status, and don’t know what the heck I should be eating.

    If someone from this site who has kept up with all the research could give a summary of what they have learned, it would be much appreciated.

    Thank you,


    Jordan Feldman

    June 3, 2013 at 4:25 pm

  5. I found out I’m APOE e4/e4 last year and since then I’ve been voraciously learning stuff about how to increase my chances for a better healthy future. Your blog is very informative and helpful for all of the E4/E4 in the world. Keep up the good work and millions of thanks.


    July 24, 2013 at 3:15 am

  6. Great topic here. Again, a whole foods diet / primal diet is preferred. It is the combination of processed foods that these genetic markers were based on! – Dr Jeff


    August 12, 2013 at 2:31 pm

  7. Just found your blog by googling “ApoE 4 diet”. I’d like to make a counter hypothesis regarding diets. The infamous “low-fat diet” has been wreaking havoc on the health of millions of Americans the past 20-30 years. I’ve recently learned about The New Atkins Diet from author Dr. Eric Westman from an online weight loss course from American Association of Antiaging Medicine (A4M). I switched to “The New Atkins Diet” 6 days ago, which is a form of ketogenic diet (low carbohydrate, high fat, moderate protein). My blood pressure, blood sugar, and weight have responded markedly favorably in just 6 days; better than with any pharmaceutical or supplement I’ve ever tried! Could ApoE 4 carriers actually benefit from saturated fat if they abstained from all sweets and starches? Isn’t that how our Paleo ancestors ate?

    Janet Kirby, MD

    August 29, 2013 at 11:33 pm

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